The relationship between decreased 5-hydroxyindole metabolism and mental defect in phenylketonuria.
نویسندگان
چکیده
In 1957 we demonstrated a defect of 5-hydroxyindole metabolism in 10 patients with phenylketonuria and suggested that, in view of the probable importance of 5-hydroxytryptamine (5HT) in normal brain function, this deficiency might be a factor in the mental defect (Pare, Sandler and Stacey, 1957). In the work described below, the previous findings are extended and the relationship of the 5-hydroxyindole deficiency to the mental defect is examined further.
منابع مشابه
On the Mechanism of the Brain Serotonin Depletion in Experimental Phenylketonuria.
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عنوان ژورنال:
- Archives of disease in childhood
دوره 34 شماره
صفحات -
تاریخ انتشار 1959